Gene expression profiling demonstrates that TGF- 1 signals exclusively through receptor complexes involving Alk5 and identifies targets of TGF- signaling
نویسندگان
چکیده
Göran Karlsson, Yingchun Liu, Jonas Larsson, Marie-José Goumans, Ju-Seog Lee, Snorri S. Thorgeirsson, Markus Ringnér, and Stefan Karlsson Department of Molecular Medicine and Gene Therapy, Institute of Laboratory Medicine, and The Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University Hospital, Lund, Sweden; Complex Systems Division, Department of Theoretical Physics, Lund University, Lund, Sweden; Department of Cardiology, Heart Lung Center, Utrecht, the Netherlands; and Laboratory of Experimental Carcinogenesis, National Cancer Institute, Bethesda, Maryland
منابع مشابه
Gene expression profiling demonstrates that TGF-beta1 signals exclusively through receptor complexes involving Alk5 and identifies targets of TGF-beta signaling.
Transforming growth factor-beta1 (TGF-beta) regulates cellular functions like proliferation, differentiation, and apoptosis. On the cell surface, TGF-beta binds to receptor complexes consisting of TGF-beta receptor type II (TbetaRII) and activin-like kinase receptor-5 (Alk5), and the downstream signaling is transduced by Smad and MAPK proteins. Recent data have shown that alternative receptor c...
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تاریخ انتشار 2004